Nearly half of aHUS patients have gain-of-function mutations in at least one of the Complement components, indicating that inherited abnormalities of the immune system are implicated in disease pathogenesis.
Casi la mitad de los pacientes que sufren SUHa presentan mutaciones de ganancia de función en al menos uno de los componentes del complemento.
C3 and C4 are the complement components measured most often.
Inherited or acquired deficiencies or abnormalities in one or more of the complement components may adversely affect the integrity and function of the immune system.
Las deficiencias heredadas o adquiridas u otras anomalías en uno o más componentes del complemento pueden afectar de manera adversa a la integridad de la funcionalidad del sistema inmune.
The proenzyme cleaves the complement components C4 and C2.
The project was based on an antibody against the complement component 5 (C5) developed by the industrial partner of the consortium under the trade name Mubodina.
El proyecto investigó un anticuerpo contra el componente 5 del complemento (C5) sintetizado por un socio del consorcio bajo el nombre comercial de Mubodina.
The complement component (protein) C4, is a substrate for activated C1s.
Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta).
La decorina parece influenciar el proceso de fibrilogénesis, aunque también interacciona con fibronectina, trombospondina, complejo C1Q, receptor del factor de crecimiento epidérmico (EGFR) y factor de crecimiento transformante beta (TGF-beta).
The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY.
New data demonstrated that when exposed to apabetalone, primary human liver cells significantly downregulate the expression of complement components.
Los nuevos datos demuestran que cuando se expone a apabetalone, las células humanas primarias reducen la regulación de forma considerable sobre la expresión de los componentes de complementos.
When carrying out the assays, indexes were used for the determination of the intrathecal synthesis of complement components and immunoglobulins.
La determinación de la síntesis intratecal de estos componentes del sistema de complemento es útil para discriminar inmunodeficiencias y entender el comportamiento de la enfermedad.
C3 and C4 are the most commonly measured complement components.
A 105-kDa serum glycoprotein with significant homology to the other late complement components, C7-C9.
Glicoproteina plasmática de 105 kDa con significativa homología con los otros últimos componentes del complemento, C7-C9.
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