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sequence alignment

Definition

arrangement of sequences to compare matching positions and highlight similarities ... See more

Translation of "sequence alignment" in Chinese

Definition NEW

序列比对

Global multiple nucleotide or peptide sequence alignment and phylogenetic analysis

球形复合核苷酸或氨基酸序列比对和系统发育分析

Proteins that do not share a common ancestor are very unlikely to show statistically significant sequence similarity, making sequence alignment a powerful tool for identifying the members of protein families.

不共享共同祖先的蛋白质不太可能显示统计学上显着的序列相似性，使序列比对成为识别蛋白质家族成员的有力工具。

Since the primary sequences of VIM metallo β-lactamases are now available, along with structure and kinetic data for some of them, their essential residues for catalyzed hydrolysis of carbapenems was studied using bioinformatics methods. Through sequence alignment and analysis of the structure-function relationship, conserved(ligand) residues binding to Zn(II) as active sites and the effects of L3 loop on the hydrolysis of carbapenems were identified.

以VIM型金属β-内酰胺酶为例，用生物信息学方法，通过对14种VIM型氨基酸序列比对以及结合动力学参数系统分析其结构和功能的关系，确定了结合Zn（II）发挥催化作用的保守残基，还发现L3环区也影响碳青霉烯类的水解。

DNA sequencing and sequence alignment

DNA测序及序列比对。

Upon completion of this module, you will be able to: describe dynamic programming based sequence alignment algorithms; differentiate between the Needleman-Wunsch algorithm for global alignment and the Smith-Waterman algorithm for local alignment; examine the principles behind gap penalty and time complexity calculation which is crucial for you to apply current bioinformatic tools in your research; experience the discovery of Smith-Waterman algorithm with Dr. Michael Waterman himself.

序列比对完成本模块的课程后你将可以：掌握基于动态规划编程思想的序列比对算法；区分Needleman-Wunsch全局比对算法和Smith-Waterman局部比对算法；了解空位罚分背后的原理和计算算法的复杂度将帮助你在你自己的研究中应用现有的生物信息学工具；你还可以一睹Smith-Waterman算法的发明人Michael Waterman博士的风采。

Now let's start our second topic: Sequence Alignment.

下面，让我们开始序列比对

For example, in 2013, a Fast Optimal Global Sequence Alignment Algorithm (FOGSAA), suggested alignment of nucleotide/protein sequences faster than other optimal global alignment methods, including the Needleman-Wunsch algorithm.

例如，在2013年，快速优化整体序列比对算法（FOGSAA），建议比其他最佳全局比对的方法，其中包括中的Needleman-Wunsch算法更快核苷酸/蛋白质序列的比对。

Data mining tools such as cluster analysis, sequence alignment and pattern matching

数据挖掘的工具，比如聚类分析、字符串对齐 和模式匹配

Amino acid sequence alignment showing conservation of Phenylalanine 275 in multiple species.

氨基酸序列对阵图，显示了275位苯丙氨酸在多种族中的高度保守。

All the comparison results of P450 protein crystal structures provided the basis for structure based sequence alignment of cytochrome P450 proteins.

P450晶体结构比较结果为P450超家族蛋白质基于结构的序列联配方法提供了依据。