Allerdings konnte die AKAP-PKA-Interaktion nicht als Angriffspunkt von FMP-API-2 verifiziert werden. Dieser wird in zukünftigen Studien zu definieren sein.
However, the AKAP-PKA interaction could not be confirmed as the target of FMP- API-2, which will have to be defined in future work.
Other results
Zwei der identifizierten Substanzen, die die AKAP-PKA-Interaktion konzentrationsabhängig hemmen (FMP-API-1 und 2, mit IC50-Werten von 23 µM bzw. 1 µM), wurden näher charakterisiert.
Two of the identified hits inhibiting the AKAP18PKA interaction concentration-dependently (FMP-API-1 and -2, IC50 values of 23 and 1 µM, respectively) were characterised.
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