The interlaced elements of the puzzle made it particularly difficult to solve.
Finding affordable housing can be particularly difficult in a metropolitan city.
If you are too dependent on routine, change can be particularly difficult.
Dermatitis is particularly difficult to treat and the sensitisation is irreversible.
The families of wanted people are in a particularly difficult situation.
Las familias de los fugitivos se encuentran en una situación muy difícil.
Once grasped, this maka-feke is particularly difficult to abandon.
Una vez aferrado a él, ese maka-feke es muy difícil de abandonar.
Landing a job during an economic downturn can be particularly difficult.
Conseguir empleo durante una recesión económica puede ser particularmente difícil.
Such challenges have proved particularly difficult for small and medium-sized enterprises.
She often asks for help when her schoolwork gets particularly difficult.
Responding to their needs is particularly difficult and requires increased efforts.
Satisfacer sus necesidades es particularmente difícil y exige cada vez más esfuerzos.
Leave tasks that are particularly difficult to concentrate on before lunch.
Historically, the night was a particularly difficult time for humanity.
Históricamente, la noche fue un momento particularmente difícil para la humanidad.
However, breeding for disease resistance is particularly difficult with banana plants.
Sin embargo, obtener resistencia a enfermedades es especialmente difícil con los bananeros.