Planning permission is crucial for any significant changes to public buildings or spaces.
Dwindling profits forced the company to make significant changes to its operations.
Her routine includes a smoke test after any significant changes in the code.
The participant's self-report reflected significant changes in their emotional state.
He strenuously challenged the outdated policies, urging for significant changes to be made.
Er stellte die veralteten Richtlinien energisch in Frage und drängte auf wesentliche Änderungen.
It is difficult to detect without significant changes in a blood test.
Es ist schwer zu erkennen, ohne wesentliche Änderungen in einer Blutprobe.
The pointing critique in the article brought about significant changes in policy.
They seem unaware of the significant changes happening in their community.
The surveyed area showed significant changes in the landscape after the storm.
The new policy will bring about significant changes in our work environment.
Her election might usher in significant changes to the education system.
The protest movement set in motion significant changes in social policies.
Their advocacy efforts led to significant changes in local education policies.